Quantifying Treatment Benefit in Molecular Subgroups to Assess a Predictive Biomarker
نویسندگان
چکیده
منابع مشابه
A reconstructed melanoma data set for evaluating differential treatment benefit according to biomarker subgroups
The data presented in this article are related to the research article entitled "Measuring differential treatment benefit across marker specific subgroups: the choice of outcome scale" (Satagopan and Iasonos, 2015) [1]. These data were digitally reconstructed from figures published in Larkin et al. (2015) [2]. This article describes the steps to digitally reconstruct patient-level data on time-...
متن کاملA Molecular Signature of Mouse NASH: A Step Closer to a Human Predictive Biomarker?
ibrosis is the single best predictor of clinical outFcomes in patients with nonalcoholic steatohepatitis (NASH). Advanced fibrosis portends liver-related mortality and determines the need for liver transplantation. Current diagnostic tools assess the presence of hepatic fibrosis but do not predict its development in patients at risk. Risk stratification based on propensity for liver fibrosis is...
متن کاملIn response to cost-benefit of vertebral augmentation: how to assess the benefit.
Letter to the editor: We read the article “Vertebral augmentation versus conservative therapy for emergently admitted vertebral compression deformities: An economic analysis” (Pain Physician 2013; 16:441-445) (1) with great interest. The authors compared 39 inpatients who had undergone vertebral augmentation (VA) with 209 medically treated patients. The authors found that daily cost was the sam...
متن کاملUsing Modified RECIST and Alpha-Fetoprotein Levels to Assess Treatment Benefit in Hepatocellular Carcinoma.
BACKGROUND AND AIMS Assessing treatment responses in hepatocellular carcinoma (HCC) is challenging, and alternative radiologic methods of measuring treatment response are required. Modified Response Evaluation Criteria in Solid Tumors (mRECIST) for HCC and alpha-fetoprotein (AFP) levels were assessed in a post hoc analysis of a phase II study of brivanib, a selective dual inhibitor of fibroblas...
متن کاملQuantifying manganese in lymphocytes to assess manganese nutritional status.
To clarify whether manganese nutritional status is better reflected by the manganese concentration in lymphocytes or in whole blood, we injected manganese solutions intravenously into manganese-deficient rats and determined manganese concentrations in lymphocytes, whole blood, and various tissues. The manganese concentrations in lymphocytes and tissues, but not in whole blood, were significantl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2016
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-15-2517